In a dramatic move, Monsanto has withdrawn its genetically modified (GM) maize, LY038 from commercial approval in Europe after safety concerns prompted the European Food Safety Authority (EFSA) to request further evidence from the company .
At the end of April 2009, two letters were sent to EFSA by Monsanto's European subsidiary company Renessen, withdrawing applications originally submitted in 2005 . The whole episode was shrouded in secrecy before being uncovered by Dr. Brian John of GM-Free Cymru. There has been no mainstream press report, and no record on the EFSA website. Not only LY038, but also the stacked variety LY038 x MON810 - derived from a cross between LY038 and another GM variety MON810 - has been withdrawn. MON810 is currently banned in many countries in Europe  Europe Holds the Key to a GM-Free World, 5th Conference of GM-Free Regions, Food & Democracy ( SiS 43), and has its own hazards [4-6] ( GM Maize Disturbs Immune System of Young and Old Mice , GM Maize Reduces Fertility & Deregulates Genes in Mice , SiS 41; MON810 Genome Rearranged Again , SiS 39).
Like other “nutritionally enhanced” GMOs, LY038 is created by grossly unbalancing the metabolic network ; and that is where the metabolic hazards arise. It is well known that overdose of many single nutritional factors is toxic, and it is not surprising that overproduction of any single metabolite creates further toxicities. Another case in point is the notorious ‘Golden Rice', now mired in controversy as phase 2 clinical trials have been conducted on children with unapproved experimental events. It is well known that high concentrations of pro-Vitamin A can cause birth defects and developmental abnormalities, and the potential for further toxicities in Golden Rice is uncomfortably high  ( The Golden Rice Scandal Unfolds , SiS 42).
However, there are also important hazards unique to each GMO, and in the case of LY038, it is due to the high concentrations of the amino acid lysine and derivatives - saccharopine, a -aminoadipic acid (a neurotoxin), pipecolic acid and cadaverine – present in the grain [9, 10] .
The excerpts above were taken directly from ISIS Press Release 11/11/09.
For the complete press release please see this link: http://www.i-sis.org.uk/HighLysineGMMaize.php